Cost-Efficient Detection of <i>NTRK1/2/3</i> Gene Fusions: Single-Center Analysis of 8075 Tumor Samples

Cost-Efficient Detection of <i>NTRK1/2/3</i> Gene Fusions: Single-Center Analysis of 8075 Tumor Samples

The majority of <i>NTRK1</i>, <i>NTRK2</i>, and <i>NTRK3</i> rearrangements result in increased expression of the kinase portion of the involved gene due to its fusion to an actively transcribed gene partner. Consequently, the analysis of 5′/3′-end expression imba...

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Bibliographic Details
Main Authors: Aleksandr A. Romanko, Rimma S. Mulkidjan, Vladislav I. Tiurin, Evgeniya S. Saitova, Elena V. Preobrazhenskaya, Elena A. Krivosheyeva, Natalia V. Mitiushkina, Anna D. Shestakova, Evgeniya V. Belogubova, Alexandr O. Ivantsov, Aglaya G. Iyevleva, Evgeny N. Imyanitov
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>NTRK1</i>
<i>NTRK2</i>
<i>NTRK3</i>
fusion
unbalanced expression
PCR
Online Access:https://www.mdpi.com/1422-0067/24/18/14203

Internet

https://www.mdpi.com/1422-0067/24/18/14203

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