Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes

Red blood cell blood group A antigen level affects the ability of heparin and PfEMP1 antibodies to disrupt Plasmodium falciparum rosettes

Abstract Background The histo-blood group ABO system has been associated with adverse outcomes in COVID-19, thromboembolic diseases and Plasmodium falciparum malaria. An integral part of the severe malaria pathogenesis is rosetting, the adherence of parasite infected red blood cells (RBCs) to uninfe...

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Bibliographic Details
Main Authors: Pontus Hedberg, Madle Sirel, Kirsten Moll, Mpungu Steven Kiwuwa, Petter Höglund, Ulf Ribacke, Mats Wahlgren
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Malaria Journal
Subjects:
Malaria
Plasmodium falciparum
Rosetting
Histo-blood group ABO system
Online Access:https://doi.org/10.1186/s12936-021-03975-w

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