Functional Analysis of Feedback Inhibition-Insensitive Variants of N-Acetyl Glutamate Kinase Found in Sake Yeast Mutants with Ornithine Overproduction

Functional Analysis of Feedback Inhibition-Insensitive Variants of N-Acetyl Glutamate Kinase Found in Sake Yeast Mutants with Ornithine Overproduction

ABSTRACT In the yeast Saccharomyces cerevisiae, N-acetyl glutamate kinase (NAGK), which catalyzes the phosphorylation of N-acetyl glutamate to form N-acetyl glutamyl-5-phosphate, is one of the rate-limiting enzymes in the ornithine and arginine biosynthetic pathways. NAGK activity is strictly regula...

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Bibliographic Details
Main Authors: Masataka Ohashi, Shota Isogai, Hiroshi Takagi
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:Microbiology Spectrum
Subjects:
Saccharomyces cerevisiae
sake yeast
ornithine
N-acetyl glutamate kinase
allosteric regulation
feedback inhibition
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00822-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.00822-22

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