Immortal time bias for life-long conditions in retrospective observational studies using electronic health records

Abstract Background Immortal time bias is common in observational studies but is typically described for pharmacoepidemiology studies where there is a delay between cohort entry and treatment initiation. Methods This study used the Clinical Practice Research Datalink (CPRD) and linked national morta...

Full description

Bibliographic Details
Main Authors: Freya Tyrer, Krishnan Bhaskaran, Mark J. Rutherford
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Medical Research Methodology
Subjects:
Online Access:https://doi.org/10.1186/s12874-022-01581-1