Randomness and optimality in enhanced DNA ligation with crowding effects
Enzymatic ligation is essential for the synthesis of long DNA. However, a number of ligated products exponentially decay as DNA synthesis proceeds randomly. The control of ligation randomness is important to suppress exponential decay and achieve efficient synthesis of long DNA. This study analyzes...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2020-03-01
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| Series: | Physical Review Research |
| Online Access: | http://doi.org/10.1103/PhysRevResearch.2.013360 |