Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Reciprocal regulation of SIRT1 and AMPK by Ginsenoside compound K impedes the conversion from plasma cells to mitigate for podocyte injury in MRL/lpr mice in a B cell-specific manner

Background: Deposition of immune complexes drives podocyte injury acting in the initial phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly, targeting B cell subsets represents a potential therapeutic approach for LN. Ginsenoside compound K (CK), a bioavailable compo...

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Bibliographic Details
Main Authors: Ziyu Song, Meng Jin, Shenglong Wang, Yanzuo Wu, Qi Huang, Wangda Xu, Yongsheng Fan, Fengyuan Tian
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Journal of Ginseng Research
Subjects:
Ginsenoside CK
Lupus nephritis
Podocyte
Plasma cell
Online Access:http://www.sciencedirect.com/science/article/pii/S1226845323001616

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http://www.sciencedirect.com/science/article/pii/S1226845323001616

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