Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria. In this work, we have described the mode of action of the...

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Bibliographic Details
Main Authors: Diana Machado, Laura Fernandes, Sofia S. Costa, Rolando Cannalire, Giuseppe Manfroni, Oriana Tabarrini, Isabel Couto, Stefano Sabatini, Miguel Viveiros
Format: Article
Language:English
Published: PeerJ Inc. 2017-04-01
Series:PeerJ
Subjects:
Efflux inhibitor
Antibiotic synergism
AcrAB
Membrane potential
Membrane permeability
RND
Online Access:https://peerj.com/articles/3168.pdf

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https://peerj.com/articles/3168.pdf

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