Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations

Mutational signature analyses in multi-child families reveal sources of age-related increases in human germline mutations

Abstract Whole-genome sequencing studies of parent–offspring trios have provided valuable insights into the potential impact of de novo mutations (DNMs) on human health and disease. However, the molecular mechanisms that drive DNMs are unclear. Studies with multi-child families can provide important...

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Main Authors: Habiballah Shojaeisaadi, Andrew Schoenrock, Matthew J. Meier, Andrew Williams, Jill M. Norris, Nicholette D. Palmer, Carole L. Yauk, Francesco Marchetti
格式: 文件
语言:English
出版: Nature Portfolio 2024-11-01
丛编:Communications Biology
在线阅读:https://doi.org/10.1038/s42003-024-07140-2

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https://doi.org/10.1038/s42003-024-07140-2

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