Positive feedback regulation of frizzled-7 expression robustly shapes a steep Wnt gradient in Xenopus heart development, together with sFRP1 and heparan sulfate

Secreted molecules called morphogens govern tissue patterning in a concentration-dependent manner. However, it is still unclear how reproducible patterning can be achieved with diffusing molecules, especially when that patterning concerns differentiation of thin tissues. Wnt is a morphogen that orga...

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Main Authors: Takayoshi Yamamoto, Yuta Kambayashi, Yuta Otsuka, Boni A Afouda, Claudiu Giuraniuc, Tatsuo Michiue, Stefan Hoppler
格式: 文件
语言:English
出版: eLife Sciences Publications Ltd 2022-08-01
丛编:eLife
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在线阅读:https://elifesciences.org/articles/73818