Spironolactone Induces Vasodilation by Endothelium-Dependent Mechanisms Involving NO and by Endothelium-Independent Mechanisms Blocking Ca<sup>2+</sup> Channels

Spironolactone Induces Vasodilation by Endothelium-Dependent Mechanisms Involving NO and by Endothelium-Independent Mechanisms Blocking Ca<sup>2+</sup> Channels

Background: Spironolactone (SPI) is a diuretic widely used to treat cardiovascular diseases (CVD) and is non-specific for mineralocorticoid receptors (MR) and with an affinity for progesterone (PR) and androgen (AR) receptors. Since 2009, it has been suggested that pharmaceuticals are emerging conta...

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Bibliographic Details
Main Authors: Margarida Lorigo, João Amaro, Elisa Cairrao
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Journal of Xenobiotics
Subjects:
mineralocorticoid receptor antagonist
cardiovascular
endocrine-disrupting chemical
rat aorta
pharmacology
vasodilation
Online Access:https://www.mdpi.com/2039-4713/14/1/20

Internet

https://www.mdpi.com/2039-4713/14/1/20

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