Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus

Bactericidal Activity of the Bacterial ATP Synthase Inhibitor Tomatidine and the Combination of Tomatidine and Aminoglycoside Against Persistent and Virulent Forms of Staphylococcus aureus

Tomatidine (TO), a steroid alkaloid, exerts a strong bactericidal activity on the infection-persistent phenotype of Staphylococcus aureus, the small-colony variant (SCV), with a minimal inhibitory concentration (MIC) of 0.06 μg/ml. Also, the combination of TO to an aminoglycoside (AMG) shows a stron...

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Bibliographic Details
Main Authors: Jean-Philippe Langlois, Guillaume Millette, Isabelle Guay, Alexis Dubé-Duquette, Suzanne Chamberland, Pierre-Étienne Jacques, Sébastien Rodrigue, Kamal Bouarab, Éric Marsault, François Malouin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Microbiology
Subjects:
Staphylococcus aureus
small-colony variant
ATP synthase inhibitor
tomatidine
aminoglycoside
mode of action
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.00805/full

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https://www.frontiersin.org/article/10.3389/fmicb.2020.00805/full

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