SIRT1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction

SIRT1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction

BackgroundPostoperative cognitive dysfunction (POCD) is a debilitating neurological complication in surgical patients. Current research has focused mainly on microglial activation, but less is known about the resultant neuronal synaptic changes. Recent studies have suggested that Sirtuin-1 (SIRT1) p...

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Bibliographic Details
Main Authors: Yi Sun, Yuzhu Wang, Fan Ye, Victoria Cui, Dandan Lin, Hui Shi, Yan Zhang, Anshi Wu, Changwei Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
SIRT1
microglial activation
synaptic engulfment
neuroinflammation
postoperative cognitive dysfunction
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.943842/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2022.943842/full

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