ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes

ER Unfolded Protein Response in Liver In Vivo Is Characterized by Reduced, Not Increased, De Novo Lipogenesis and Cholesterol Synthesis Rates with Uptake of Fatty Acids from Adipose Tissue: Integrated Gene Expression, Translation Rates and Metabolic Fluxes

The unfolded protein response in the endoplasmic reticulum (UPR<sup>ER</sup>) is involved in a number of metabolic diseases. Here, we characterize UPR<sup>ER</sup>-induced metabolic changes in mouse livers in vivo through metabolic labeling and mass spectrometric analysis of...

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Bibliographic Details
Main Authors: Catherine P. Ward, Lucy Peng, Samuel Yuen, Michael Chang, Rozalina Karapetyan, Edna Nyangau, Hussein Mohammed, Hector Palacios, Naveed Ziari, Larry K. Joe, Ashley E. Frakes, Mohamad Dandan, Andrew Dillin, Marc K. Hellerstein
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
ER stress
proteostasis
UPR
lipid metabolism
metabolism
Online Access:https://www.mdpi.com/1422-0067/23/3/1073

Internet

https://www.mdpi.com/1422-0067/23/3/1073

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