PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment

The poly (ADP-ribose) polymerase (PARP1) interacts with the telomere factor TRF1 and loss of PARP1 results in telomere fragility and impairment of helicases -TRF1 complex assembly.

Bibliographic Details
Main Authors: C. Maresca, A. Dello Stritto, C. D’Angelo, E. Petti, A. Rizzo, E. Vertecchi, F. Berardinelli, L. Bonanni, A. Sgura, A. Antoccia, G. Graziani, A. Biroccio, E. Salvati
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04596-6

Internet

https://doi.org/10.1038/s42003-023-04596-6

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