Enhancement of Haloperidol Binding Affinity to Dopamine Receptor via Forming a Charge-Transfer Complex with Picric Acid and 7,7,8,8-Tetracyanoquinodimethane for Improvement of the Antipsychotic Efficacy

Enhancement of Haloperidol Binding Affinity to Dopamine Receptor via Forming a Charge-Transfer Complex with Picric Acid and 7,7,8,8-Tetracyanoquinodimethane for Improvement of the Antipsychotic Efficacy

Haloperidol (HPL) is a typical antipsychotic drug used to treat acute psychotic conditions, delirium, and schizophrenia. Solid charge transfer (CT) products of HPL with 7,7,8,8-tetracyanoquinodimethane (TCNQ) and picric acid (PA) have not been reported till date. Therefore, we conducted this study t...

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Bibliographic Details
Main Authors: Abdulhakeem S. Alamri, Majid Alhomrani, Walaa F. Alsanie, Hussain Alyami, Sonam Shakya, Hamza Habeeballah, Abdulwahab Alamri, Omar Alzahrani, Ahmed S. Alzahrani, Heba A. Alkhatabi, Raed I. Felimban, Abdulhameed Abdullah Alhabeeb, Bassem M. Raafat, Moamen S. Refat, Ahmed Gaber
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Molecules
Subjects:
charge transfer
haloperidol
π-acceptors
antipsychotics
Online Access:https://www.mdpi.com/1420-3049/27/10/3295

Internet

https://www.mdpi.com/1420-3049/27/10/3295

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