Surface plasmon resonance imaging of the conversion of clustered DNA lesions into double strand breaks by Fpg protein

Surface plasmon resonance imaging of the conversion of clustered DNA lesions into double strand breaks by Fpg protein

Ionizing radiations induce clustered damage sites known to be severely challenging for the cell's repair machinery. In the present study, we have grafted on a biochip four synthetic oligonucleotide duplexes containing either a single 8-oxoguanine, a single 2'-deoxyribose abasic site or two...

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Bibliographic Details
Main Authors: Muriel Jourdan, Julia Pingel, Arnaud Buhot, Thierry Livache, Jean-François Constant
Format: Article
Language:English
Published: AIMS Press 2015-11-01
Series:AIMS Materials Science
Subjects:
surface plasmon resonance imaging
DNA double strand break
Fpg
8-oxoguanine
abasic site
DNA cluster lesion
Online Access:http://www.aimspress.com/Materials/article/514/fulltext.html

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http://www.aimspress.com/Materials/article/514/fulltext.html

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