Expanding the Diversity at the C-4 Position of Pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones to Achieve Biological Activity against ZAP-70

Expanding the Diversity at the C-4 Position of Pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones to Achieve Biological Activity against ZAP-70

Pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-ones have attracted widespread interest due to their similarity with nitrogenous bases found in DNA and RNA and their potential applicability as tyrosine kinase inhibitors. Such structures, presenting up to five diversity centers, ha...

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Bibliographic Details
Main Authors: Victor Masip, Ángel Lirio, Albert Sánchez-López, Ana B. Cuenca, Raimon Puig de la Bellacasa, Pau Abrisqueta, Jordi Teixidó, José I. Borrell, Albert Gibert, Roger Estrada-Tejedor
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
pyrido[2,3-<i>d</i>]pyrimidines
cross-coupling
tyrosine kinase inhibitors
ZAP-70
Online Access:https://www.mdpi.com/1424-8247/14/12/1311

Internet

https://www.mdpi.com/1424-8247/14/12/1311

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