A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus‐like Disease in Mice

A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus‐like Disease in Mice

Objective To determine if single‐nucleotide polymorphisms (SNPs) in DNA repair genes are enriched in individuals with systemic lupus erythematosus (SLE) and if they are sufficient to confer a disease phenotype in a mouse model. Methods Human exome chip data of 2499 patients with SLE and 1230 healthy...

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Bibliographic Details
Main Authors: Rithy Meas, Joanne Nititham, Kimberly E. Taylor, Stephen Maher, Kaylyn Clairmont, Kelly E. W. Carufe, Michael Kashgarian, Timothy Nottoli, Ana Cheong, Zachary D. Nagel, Patrick M. Gaffney, Lindsey A. Criswell, Joann B. Sweasy
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:ACR Open Rheumatology
Online Access:https://doi.org/10.1002/acr2.11471

Internet

https://doi.org/10.1002/acr2.11471

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