Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, characterized by disruption of the early embryonic events of central nervous system formation. NTDs have long been known to exhibit a strong genetic dependence, yet the identity of the genetic determina...

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Bibliographic Details
Main Authors: Jennifer N. Murdoch, Christine Damrau, Anju Paudyal, Debora Bogani, Sara Wells, Nicholas D. E. Greene, Philip Stanier, Andrew J. Copp
Format: Article
Language:English
Published: The Company of Biologists 2014-10-01
Series:Disease Models & Mechanisms
Subjects:
Neural tube defects
Planar cell polarity
Genetic interactions
Craniorachischisis
Multiple heterozygosity
Online Access:http://dmm.biologists.org/content/7/10/1153

Internet

http://dmm.biologists.org/content/7/10/1153

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