Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML

Abstract Background Acute myeloid leukemia (AML) patients with a high allelic burden of an internal tandem duplication (ITD)-mutated FMS-like Tyrosine Kinase-3 (FLT3) have a dismal outcome. FLT3ITD triggers the proliferation of the quiescent hematopoietic stem cell (HSC) pool but fails to directly t...

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Bibliographic Details
Main Authors: Maria Solovey, Ying Wang, Christian Michel, Klaus H. Metzeler, Tobias Herold, Joachim R. Göthert, Volker Ellenrieder, Elisabeth Hessmann, Stefan Gattenlöhner, Andreas Neubauer, Dinko Pavlinic, Vladimir Benes, Oliver Rupp, Andreas Burchert
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Hematology & Oncology
Subjects:
FLT3ITD
Acute myeloid leukemia
Hematopoietic stem cells
NFATC1
Drug resistance
Online Access:http://link.springer.com/article/10.1186/s13045-019-0765-y

Internet

http://link.springer.com/article/10.1186/s13045-019-0765-y

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