Prominent epigenetic and transcriptomic changes in CD4+ and CD8+ T cells during and after pregnancy in women with multiple sclerosis and controls

Prominent epigenetic and transcriptomic changes in CD4+ and CD8+ T cells during and after pregnancy in women with multiple sclerosis and controls

Abstract Background Multiple sclerosis (MS) is a neuroinflammatory disease in which pregnancy leads to a temporary amelioration in disease activity as indicated by the profound decrease in relapses rate during the 3rd trimester of pregnancy. CD4+ and CD8+ T cells are implicated in MS pathogenesis as...

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Bibliographic Details
Main Authors: Alberto Zenere, Sandra Hellberg, Georgia Papapavlou Lingehed, Maria Svenvik, Johan Mellergård, Charlotte Dahle, Magnus Vrethem, Johanna Raffetseder, Mohsen Khademi, Tomas Olsson, Marie Blomberg, Maria C. Jenmalm, Claudio Altafini, Mika Gustafsson, Jan Ernerudh
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Pregnancy
CD4+
CD8+
T cells
Methylation
Online Access:https://doi.org/10.1186/s12974-023-02781-2

Internet

https://doi.org/10.1186/s12974-023-02781-2

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