An Amyloid-like Pathological Conformation of TDP-43 is Stabilized by Hypercooperative Hydrogen Bonds
TDP-43 is an essential RNA-binding protein forming aggregates in almost all cases of sporadic ALS and many cases of FTLD and other neurodegenerative diseases. TDP-43 consists of a folded N-terminal domain with a singular structure, two RRM RNA-binding domains, and a long disordered C-terminal regio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2016-11-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00125/full |