Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin

Mutant p53 Depletion by Novel Inhibitors for HSP40/J-Domain Proteins Derived from the Natural Compound Plumbagin

Accumulation of missense mutant p53 (mutp53) in cancers promotes malignant progression. DNAJA1, a member of HSP40 (also known as J-domain proteins: JDPs), is shown to prevent misfolded or conformational mutp53 from proteasomal degradation. Given frequent addiction of cancers to oncogenic mutp53, dep...

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Bibliographic Details
Main Authors: Mohamed Alalem, Mrinalini Bhosale, Atul Ranjan, Satomi Yamamoto, Atsushi Kaida, Shigeto Nishikawa, Alejandro Parrales, Sana Farooki, Shrikant Anant, Subhash Padhye, Tomoo Iwakuma
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
HSP40
DNAJA1
mutant p53
inhibitor
natural compound
Online Access:https://www.mdpi.com/2072-6694/14/17/4187

Internet

https://www.mdpi.com/2072-6694/14/17/4187

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