Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways.

Sprouty2 Suppresses Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells through Blockade of Smad2 and ERK1/2 Pathways.

Transforming growth factor β (TGFβ)-induced epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) plays a key role in the pathogenesis of anterior subcapsular cataract (ASC) and capsule opacification. In mouse lens, Sprouty2 (Spry2) has a negative regulatory role on TGFβ signaling....

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Bibliographic Details
Main Authors: Xuhua Tan, Yi Zhu, Chuan Chen, Xiaoyun Chen, Yingyan Qin, Bo Qu, Lixia Luo, Haotian Lin, Mingxing Wu, Weirong Chen, Yizhi Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4944964?pdf=render

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http://europepmc.org/articles/PMC4944964?pdf=render

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