Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

Ivermectin-Induced Apoptotic Cell Death in Human SH-SY5Y Cells Involves the Activation of Oxidative Stress and Mitochondrial Pathway and Akt/mTOR-Pathway-Mediated Autophagy

Ivermectin (IVM) could cause potential neurotoxicity; however, the precise molecular mechanisms remain unclear. This study explores the cytotoxicity of IVM in human neuroblastoma (SH-SY5Y) cells and the underlying molecular mechanisms. The results show that IVM treatment (2.5–15 μM) for 24 h could i...

Full description

Bibliographic Details
Main Authors: Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Antioxidants
Subjects:
ivermectin
neurotoxicity
oxidative stress
apoptosis
autophagy
Akt/mTOR pathway
Online Access:https://www.mdpi.com/2076-3921/11/5/908

Internet

https://www.mdpi.com/2076-3921/11/5/908

Similar Items