Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients

Simultaneous LC-ESI-MS/MS Quantification of Levosimendan and Its Metabolites for Therapeutic Drug Monitoring of Cardiac Surgery Patients

Levosimendan is used in severe chronic cardiac insufficiency, also within the peri-operative setting. Real-life pharmacokinetic data in surgical patients is lacking, making therapeutic drug monitoring (TDM) of levosimendan, its pharmacologically active metabolite OR-1896, and its intermediate OR-185...

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Bibliographic Details
Main Authors: Hannah Kipka, Roland Tomasi, Max Hübner, Uwe Liebchen, Christian Hagl, Klaus T. Wanner, Hanna Mannell, Georg Höfner
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Pharmaceutics
Subjects:
levosimendan
OR-1896
OR-1855
therapeutic drug monitoring (TDM)
LC-ESI-MS/MS
cardiac surgery
Online Access:https://www.mdpi.com/1999-4923/14/7/1454

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https://www.mdpi.com/1999-4923/14/7/1454

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