Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease

Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease

Accumulating evidence indicates that early adverse life experiences may be involved in the pathogenesis of Alzheimer's disease (AD). Prenatal stress (PS) can affect brain maturation and neuroimmune and metabolic interactions, leading to age-dependent cognitive deficits in offspring. However, a...

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Bibliographic Details
Main Authors: Ewa Trojan, Katarzyna Curzytek, Paulina Cieślik, Joanna M. Wierońska, Johannes Graff, Władysław Lasoń, Takashi Saito, Takaomi C. Saido, Agnieszka Basta-Kaim
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Neurobiology of Disease
Subjects:
Prenatal stress
Ageing
Alzheimer's disease
Knock-in mice (APPNL-F/NL-F)
Cognitive deficits
Insulin/IGF-1 signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123002346

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http://www.sciencedirect.com/science/article/pii/S0969996123002346

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