Transient intracellular acidification regulates the core transcriptional heat shock response
Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought to depend on ongoing protein synthesis. Here,...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2020-08-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/54880 |