Neuroprotection Targeting Protein Misfolding on Chronic Cerebral Hypoperfusion in the Context of Metabolic Syndrome

Neuroprotection Targeting Protein Misfolding on Chronic Cerebral Hypoperfusion in the Context of Metabolic Syndrome

Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH to Alzheimer's disease. Protein misfoldi...

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Bibliographic Details
Main Authors: María I. Herrera, Lucas D. Udovin, Nicolás Toro-Urrego, Carlos F. Kusnier, Juan P. Luaces, Matilde Otero-Losada, Francisco Capani
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Neuroscience
Subjects:
metabolic syndrome
chronic cerebral hypoperfusion
neuroprotection
protein misfolding
endoplasmic reticulum stress
chaperones
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00339/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00339/full

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