The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer?
Autophagy is a conserved intracellular degradation system that plays a dual role in cell death; thus, therapies targeting autophagy in cancer are somewhat controversial. Ferroptosis is a new form of regulated cell death featured with the iron-dependent accumulation of lethal lipid ROS. This pathway...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
China Anti-Cancer Association
2019-12-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1504 |
| _version_ | 1818188306356109312 |
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| author | Yulu Zhou Yong Shen Cong Chen Xinbing Sui Jingjing Yang Linbo Wang Jichun Zhou |
| author_facet | Yulu Zhou Yong Shen Cong Chen Xinbing Sui Jingjing Yang Linbo Wang Jichun Zhou |
| author_sort | Yulu Zhou |
| collection | DOAJ |
| description | Autophagy is a conserved intracellular degradation system that plays a dual role in cell death; thus, therapies targeting autophagy in cancer are somewhat controversial. Ferroptosis is a new form of regulated cell death featured with the iron-dependent accumulation of lethal lipid ROS. This pathway is morphologically, biochemically and genetically distinct from other forms of cell death. Accumulating studies have revealed crosstalk between autophagy and ferroptosis at the molecular level. In this review, we summarize the mechanisms of ferroptosis and autophagy, and more importantly, their roles in the drug resistance of cancer. Numerous connections between ferroptosis and autophagy have been revealed, and a strong causal relationship exists wherein one process controls the other and can be utilized as potential therapeutic targets for cancer. The elucidation of when and how to modulate their crosstalk using therapeutic strategies depends on an understanding of the fine-tuned switch between ferroptosis and autophagy, and approaches designed to manipulate the intensity of autophagy might be the key. |
| first_indexed | 2024-12-11T23:24:50Z |
| format | Article |
| id | doaj.art-97f325affb204aa8ae08a8f7eab790ef |
| institution | Directory Open Access Journal |
| issn | 2095-3941 2095-3941 |
| language | English |
| last_indexed | 2024-12-11T23:24:50Z |
| publishDate | 2019-12-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-97f325affb204aa8ae08a8f7eab790ef2022-12-22T00:46:13ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412019-12-0116463064610.20892/j.issn.2095-3941.2019.0158CBM-2019-0158The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer?Yulu Zhou0Yong Shen1Cong Chen2Xinbing Sui3Jingjing Yang4Linbo Wang5Jichun Zhou6Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaDepartment of Breast Surgery, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaDepartment of Medical Oncology, Holistic Integrative Oncology Institutes and Holistic Integrative Cancer Center of Traditional Chinese and Western Medicine, The Affiliated Hospital of Hangzhou Normal University, College of Medicine, Hangzhou Normal University, Hangzhou 310012, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaDepartment of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinaAutophagy is a conserved intracellular degradation system that plays a dual role in cell death; thus, therapies targeting autophagy in cancer are somewhat controversial. Ferroptosis is a new form of regulated cell death featured with the iron-dependent accumulation of lethal lipid ROS. This pathway is morphologically, biochemically and genetically distinct from other forms of cell death. Accumulating studies have revealed crosstalk between autophagy and ferroptosis at the molecular level. In this review, we summarize the mechanisms of ferroptosis and autophagy, and more importantly, their roles in the drug resistance of cancer. Numerous connections between ferroptosis and autophagy have been revealed, and a strong causal relationship exists wherein one process controls the other and can be utilized as potential therapeutic targets for cancer. The elucidation of when and how to modulate their crosstalk using therapeutic strategies depends on an understanding of the fine-tuned switch between ferroptosis and autophagy, and approaches designed to manipulate the intensity of autophagy might be the key.http://www.cancerbiomed.org/index.php/cocr/article/view/1504autophagyferroptosiscrosstalkcancerdrug resistance |
| spellingShingle | Yulu Zhou Yong Shen Cong Chen Xinbing Sui Jingjing Yang Linbo Wang Jichun Zhou The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer? Cancer Biology & Medicine autophagy ferroptosis crosstalk cancer drug resistance |
| title | The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer? |
| title_full | The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer? |
| title_fullStr | The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer? |
| title_full_unstemmed | The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer? |
| title_short | The crosstalk between autophagy and ferroptosis: what can we learn to target drug resistance in cancer? |
| title_sort | crosstalk between autophagy and ferroptosis what can we learn to target drug resistance in cancer |
| topic | autophagy ferroptosis crosstalk cancer drug resistance |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/1504 |
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