Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus

Pathogenesis of Frontotemporal Lobar Degeneration: Insights From Loss of Function Theory and Early Involvement of the Caudate Nucleus

Frontotemporal lobar degeneration (FTLD) is a group of clinically, pathologically and genetically heterogeneous neurodegenerative disorders that involve the frontal and temporal lobes. Behavioral variant frontotemporal dementia (bvFTD), semantic dementia (SD), and progressive non-fluent aphasia (PNF...

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Bibliographic Details
Main Authors: Gen Sobue, Shinsuke Ishigaki, Hirohisa Watanabe
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Neuroscience
Subjects:
frontotemporal lobar degeneration
loss of function
tau proteins
fused in sarcoma/translated in liposarcoma
amyotrophic lateral sclerosis
TDP-43 proteinopathies
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00473/full

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https://www.frontiersin.org/article/10.3389/fnins.2018.00473/full

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