The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation

The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation

Summary: Heme is an iron-containing porphyrin of vital importance for cell energetic metabolism. High rates of heme synthesis are commonly observed in proliferating cells. Moreover, the cell-surface heme exporter feline leukemia virus subgroup C receptor 1a (FLVCR1a) is overexpressed in several tumo...

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Main Authors: Veronica Fiorito, Anna Lucia Allocco, Sara Petrillo, Elena Gazzano, Simone Torretta, Saverio Marchi, Francesca Destefanis, Consiglia Pacelli, Valentina Audrito, Paolo Provero, Enzo Medico, Deborah Chiabrando, Paolo Ettore Porporato, Carlotta Cancelliere, Alberto Bardelli, Livio Trusolino, Nazzareno Capitanio, Silvia Deaglio, Fiorella Altruda, Paolo Pinton, Simone Cardaci, Chiara Riganti, Emanuela Tolosano
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
heme
ALAS1
FLVCR1a
FLVCR1
FLVCR
metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721006173

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http://www.sciencedirect.com/science/article/pii/S2211124721006173

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