RUNX3-activated apelin signaling inhibits cell proliferation and fibrosis in diabetic nephropathy by regulation of the SIRT1/FOXO pathway
Abstract Background Diabetic nephropathy is a major secondary cause of end-stage renal disease. Apelin plays an important role in the development of DN. Understanding the exact mechanism of Apelin can help expand the means of treating DN. Methods Male C57BL/6 mice was used and STZ treatment was impl...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-07-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-024-01393-x |