Precise dapagliflozin delivery by cardiac homing peptide functionalized mesoporous silica nanocarries for heart failure repair after myocardial infarction

Precise dapagliflozin delivery by cardiac homing peptide functionalized mesoporous silica nanocarries for heart failure repair after myocardial infarction

Myocardial infarction (MI) may cause irreversible damage or destroy to part of the heart muscle, affecting the heart’s ability and power to pump blood as efficiently as before, often resulting in heart failure (HF). Cardiomyocyte death and scar formation after MI may then trigger chronic neurohormon...

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Bibliographic Details
Main Authors: Lijiao You, Qing Wang, Yuhui Ma, Yunfeng Li, Hui Ye, Lingli Xu, Ming Lei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Chemistry
Subjects:
myocardial infarction
dapagliflozin
nano-targeted drugs delivery system
heart failure repair
hypoxia-inducible factor 1-α (HIF-1α)
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2022.1013910/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2022.1013910/full

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