Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination

Fluorination of silyl prosthetic groups by fluorine mediated silyl ether linker cleavage: a concept study with conditions applicable in radiofluorination

Abstract Background Positron emission tomography (PET) is a powerful tool in medical imaging, especially in combination with the PET radionuclide fluorine-18 that possesses optimal characteristics. For labelling of biomolecules and low-molecular weight tracers, fluorine-18 can be covalently bound to...

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Bibliographic Details
Main Authors: Carsten Sven Kramer, Luca Greiner, Klaus Kopka, Martin Schäfer
Format: Article
Language:English
Published: SpringerOpen 2022-06-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Fluorine-18
PET
SiFA
Solid phase synthesis
Radiofluorination
Solid support
Online Access:https://doi.org/10.1186/s41181-022-00167-y

Internet

https://doi.org/10.1186/s41181-022-00167-y

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