Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability

Lung Fibroblasts from Idiopathic Pulmonary Fibrosis Patients Harbor Short and Unstable Telomeres Leading to Chromosomal Instability

Idiopathic pulmonary fibrosis (IPF) is associated with several hallmarks of aging including telomere shortening, which can result from germline mutations in telomere related genes (TRGs). Here, we assessed the length and stability of telomeres as well as the integrity of chromosomes in primary lung...

Full description

Bibliographic Details
Main Authors: Radhia M’Kacher, Madeleine Jaillet, Bruno Colicchio, Eirini Vasarmidi, Arnaud Mailleux, Alain Dieterlen, Caroline Kannengiesser, Claire Borie, Noufissa Oudrhiri, Steffen Junker, Philippe Voisin, Eric Jeandidier, Patrice Carde, Michael Fenech, Annelise Bennaceur-Griscelli, Bruno Crestani, Raphael Borie
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Biomedicines
Subjects:
idiopathic pulmonary fibrosis
telomere dysfunction
dicentric chromosome
anaphase bridges
micronuclei
TERT
Online Access:https://www.mdpi.com/2227-9059/10/2/310

Internet

https://www.mdpi.com/2227-9059/10/2/310

Similar Items