Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway

The morbidity and mortality of primary liver cancer is one of the highest amongst all cancers. Deficiency of effective treatment and characteristics of cancer metastasis are believed to be responsible for this situation, thus a great demand is required for new agent development. Polyphyllin II (PP2)...

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Bibliographic Details
Main Authors: Dejiang Pang, Chengcheng Yang, Chao Li, Yuanfeng Zou, Bin Feng, Lixia Li, Wentao Liu, Qihui Luo, Zhengli Chen, Chao Huang
Format: Article
Language:English
Published: The Company of Biologists 2020-02-01
Series:Biology Open
Subjects:
liver cancer
polyphyllin ii
proliferation
migration and invasion
cofilin
akt/nf-κb
mmp2/mmp9
Online Access:http://bio.biologists.org/content/9/2/bio046854

Internet

http://bio.biologists.org/content/9/2/bio046854

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