In Vivo Genome-Wide Gene Expression Profiling Reveals That Haemophilus influenzae Purine Synthesis Pathway Benefits Its Infectivity within the Airways

In Vivo Genome-Wide Gene Expression Profiling Reveals That Haemophilus influenzae Purine Synthesis Pathway Benefits Its Infectivity within the Airways

ABSTRACT Haemophilus influenzae is a human-adapted bacterial pathogen that causes airway infections. Bacterial and host elements associated with the fitness of H. influenzae within the host lung are not well understood. Here, we exploited the strength of in vivo-omic analyses to study host-microbe i...

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Bibliographic Details
Main Authors: Begoña Euba, Celia Gil-Campillo, Javier Asensio-López, Nahikari López-López, Emel Sen-Kilic, Roberto Díez-Martínez, Saioa Burgui, Mariette Barbier, Junkal Garmendia
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
Haemophilus influenzae
airway infection
in vivo RNA-seq
metabolic requirements
purine synthesis
purine analogs
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00823-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.00823-23

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