A 2.8 Å Structure of Zoliflodacin in a DNA Cleavage Complex with <i>Staphylococcus aureus</i> DNA Gyrase

A 2.8 Å Structure of Zoliflodacin in a DNA Cleavage Complex with <i>Staphylococcus aureus</i> DNA Gyrase

Since 2000, some thirteen quinolones and fluoroquinolones have been developed and have come to market. The quinolones, one of the most successful classes of antibacterial drugs, stabilize DNA cleavage complexes with DNA gyrase and topoisomerase IV (topo IV), the two bacterial type IIA topoisomerases...

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Bibliographic Details
Main Authors: Harry Morgan, Magdalena Lipka-Lloyd, Anna J. Warren, Naomi Hughes, John Holmes, Nicolas P. Burton, Eshwar Mahenthiralingam, Ben D. Bax
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
zoliflodacin
quinolones
DNA gyrase
topoisomerase IV
ESKAPE
antibiotic
Online Access:https://www.mdpi.com/1422-0067/24/2/1634

Internet

https://www.mdpi.com/1422-0067/24/2/1634

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