Forskolin Sensitizes Human Acute Myeloid Leukemia Cells to H3K27me2/3 Demethylases GSKJ4 Inhibitor via Protein Kinase A

Forskolin Sensitizes Human Acute Myeloid Leukemia Cells to H3K27me2/3 Demethylases GSKJ4 Inhibitor via Protein Kinase A

Acute myeloid leukemia (AML) is an aggressive hematological malignancy occurring very often in older adults, with poor prognosis depending on both rapid disease progression and drug resistance occurrence. Therefore, new therapeutic approaches are demanded. Epigenetic marks play a relevant role in AM...

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Bibliographic Details
Main Authors: Michela Illiano, Mariarosaria Conte, Luigi Sapio, Angela Nebbioso, Annamaria Spina, Lucia Altucci, Silvio Naviglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
forskolin
leukemia
epigenetics
anticancer therapy
cell death
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00792/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00792/full

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