Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice

Neuroprotection by upregulation of the major histocompatibility complex class I (MHC I) in SOD1G93A mice

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that progressively affects motoneurons, causing muscle atrophy and evolving to death. Astrocytes inhibit the expression of MHC-I by neurons, contributing to a degenerative outcome. The present study verified the influence of interfer...

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Bibliographic Details
Main Authors: Ana Laura M. R. Tomiyama, Luciana Politti Cartarozzi, Lilian de Oliveira Coser, Gabriela Bortolança Chiarotto, Alexandre L. R. Oliveira
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amyotrophic lateral sclerosis
IFN β
ALS therapy
MHC-I
gliosis
neuroprotection
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1211486/full

Internet

https://www.frontiersin.org/articles/10.3389/fncel.2023.1211486/full

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