Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis

Dexamethasone Induces Senescence-Associated Changes in Trabecular Meshwork Cells by Increasing ROS Levels Via the TGFβ/Smad3-NOX4 Axis

Glaucoma is a serious complication of glucocorticoid (GC) therapy arising through elevations in intraocular pressure (IOP). Dexamethasone (DEX) is reported to contribute to elevated IOP through different effects on the trabecular meshwork but whether DEX contributes to glaucoma development through t...

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Bibliographic Details
Main Authors: Haijun Li, Jing Ren, Huiling Cui, Di Wang, Rumeng Zhao, Xiaohui Liu, Shuai Tian, Jing Wang, Jingyi Zhang, Peng Li, Rick F. Thorne, Shichao Duan
Format: Article
Language:English
Published: SAGE Publishing 2023-06-01
Series:Cell Transplantation
Online Access:https://doi.org/10.1177/09636897231177356

Internet

https://doi.org/10.1177/09636897231177356

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