Electrophysiological characterization of schizophrenia-associated variants in NaV1.2 sodium channel
Introduction A major pathophysiological hypothesis of schizophrenia states an increased activity of glutamatergic neurons leading to an imbalance of neural excitation and inhibition (E/I-imbalance). One potential molecular mechanism of E/I-imbalance is a dysfunction of voltage-gated sodium channels...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Cambridge University Press
2022-06-01
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Series: | European Psychiatry |
Subjects: | |
Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822019678/type/journal_article |