Myostatin/AKT/FOXO Signaling Is Altered in Human Non-Ischemic Dilated Cardiomyopathy

Myostatin/AKT/FOXO Signaling Is Altered in Human Non-Ischemic Dilated Cardiomyopathy

Disturbances in the ubiquitin proteasome system, and especially changes of the E3 ligases, are subjects of interest when searching for causes and therapies for cardiomyopathies. The aim of this study was to clarify whether the myostatin/AKT/forkhead box O (FOXO) pathway, which regulates the expressi...

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Bibliographic Details
Main Authors: Lea Hildebrandt, Maja-Theresa Dieterlen, Kristin Klaeske, Josephina Haunschild, Diyar Saeed, Sandra Eifert, Michael A. Borger, Khalil Jawad
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Life
Subjects:
heart failure
cardiomyopathy
protein breakdown
E3 ligases
FOXO
MAFbx
Online Access:https://www.mdpi.com/2075-1729/12/9/1418

Internet

https://www.mdpi.com/2075-1729/12/9/1418

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