HNF4α Acts as Upstream Functional Regulator of Intestinal Wnt3 and Paneth Cell FateSummary

Background & Aims: The intestinal epithelium intrinsically renews itself ex vivo via the proliferation of Lgr5+ intestinal stem cells, which is sustained by the establishment of an epithelial stem cell niche. Differentiated Paneth cells are the main source of epithelial-derived niche factor...

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Bibliographic Details
Main Authors: Christine Jones, Mariano Avino, Véronique Giroux, Francois Boudreau
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X22002466