Physicochemical Characterizations and Pharmacokinetic Evaluation of Pentazocine Solid Lipid Nanoparticles against Inflammatory Pain Model

Physicochemical Characterizations and Pharmacokinetic Evaluation of Pentazocine Solid Lipid Nanoparticles against Inflammatory Pain Model

Pentazocine (PTZ), a narcotic-antagonist analgesic, has been extensively used in the treatment of initial carcinogenic or postoperative pain. Hepatic first-pass metabolism results in low oral bioavailability and high dose wastage. Herein, 10 mg (-)-Pentazocine (HPLC-grade) was incorporated to solid...

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Bibliographic Details
Main Authors: Zaheer Ullah Khan, Anam Razzaq, Ahsan Khan, Naeem Ur Rehman, Hira Khan, Taous Khan, Ashraf Ullah Khan, Norah A. Althobaiti, Farid Menaa, Haroon Iqbal, Naveed Ullah Khan
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
pentazocine
solid lipid nanoparticles
oral bioavailability
first-pass metabolism
inflammation
controlled and sustained drug release
Online Access:https://www.mdpi.com/1999-4923/14/2/409

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https://www.mdpi.com/1999-4923/14/2/409

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