Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells

Modeling human brain rhabdoid tumor by inactivating tumor suppressor genes in induced pluripotent stem cells

Atypical teratoid/rhabdoid tumor (ATRT) is a rare childhood malignancy that originates in the central nervous system. Over ninety-five percent of ATRT patients have biallelic inactivation of the tumor suppressor gene SMARCB1. ATRT has no standard treatment, and a major limiting factor in therapeutic...

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Bibliographic Details
Main Authors: Timothy Hua, Yu Xue, Drishty B. Sarker, Sonia Kiran, Yan Li, Qing-Xiang Amy Sang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-01-01
Series:Bioactive Materials
Subjects:
Atypical teratoid/rhabdoid tumor
Human induced pluripotent stem cells
CRISPR/Cas9 gene editing
Tumor suppressor genes
SMARCB1
Brain tumor modeling
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X23002487

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http://www.sciencedirect.com/science/article/pii/S2452199X23002487

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