Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer

Colorectal cancer’s (CRC) ability to invade local tissues and lymph nodes and generate distant metastases is the key for TNM classification. Aspartate-β-hydroxylase (ASPH), a transmembrane protein that catalyzes Notch receptors and ligand activation, is involved in tumor invasion. Because Notch is i...

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Bibliographic Details
Main Authors: Roberto Benelli, Delfina Costa, Luca Mastracci, Federica Grillo, Mark Jon Olsen, Paola Barboro, Alessandro Poggi, Nicoletta Ferrari
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
ASPH
colorectal cancer
cell invasion
tumor budding
Online Access:https://www.mdpi.com/2072-6694/12/4/971

Internet

https://www.mdpi.com/2072-6694/12/4/971

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