Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages

Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-𝜅B-IL-6 axis of tumor-associated macrophages

Abstract Background Circular RNAs (circRNAs) have important regulatory functions in cancer, but the role of circRNAs in the tumor microenvironment (TME) remains unclear. Moreover, we also explore the effects of si-circRNAs loaded in nanoparticles as therapeutic agent for anti-tumor in vivo. Methods...

Full description

Bibliographic Details
Main Authors: Boxuan Zhou, Zhaohong Mo, Guie Lai, Xiaohong Chen, Ruixi Li, Runxin Wu, Jia Zhu, Fang Zheng
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
cSERPINE2
Tumor-associated macrophages
Exosome
Nanoparticles
Online Access:https://doi.org/10.1186/s13046-023-02620-5

Internet

https://doi.org/10.1186/s13046-023-02620-5

Similar Items