Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization

Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization

Abstract Background Inflammation and immune dysfunction with classically activated macrophages(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS). Dynamin-related protein 1 (DRP1)-dependent mitochondrial fission is a novel target for alleviating inflammatory disease...

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Bibliographic Details
Main Authors: Ze-da-zhong Su, Chun-qiu Li, Hua-wei Wang, Min-ming Zheng, Qing-wei Chen
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Translational Medicine
Subjects:
Atherosclerosis
Mdivi-1
DRP1
Mitochondrial fission
M1 polarization
NLRP3 inflammasome
Online Access:https://doi.org/10.1186/s12967-023-04270-9

Internet

https://doi.org/10.1186/s12967-023-04270-9

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